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Questions for FRACP Candidates 2011



Prepared by Dr Clare Boothroyd

One answer only for each question.
The correct answer is underlined.


Question 1

A 30 year old woman with Turner syndrome is contemplating pregnancy from the use of donated oocytes. For her case which of the following is correct :


1.  Aortic root diameter assesssment is required.

2.  Renal impairment is the commonest contraindication to pregnancy.

3.  Uterine growth is likely to be inadequate to support a pregnancy.

4.  1 and 2 are true.

5.  1,2 and 3 are true.


Question 2

Which of the following conditions is not more common in women with Turner syndrome than in normal women?


1.  Hypercholesterolemia

2.  Hypothyroidism

3.  Irritable bowel syndrome

4.  Hypertension

5.  Reduced bone density


Question 3

Which of the following statements about 45XO karyotype is untrue?


1.  45XO karyotype in the fetus is a common cause of miscarriage.

2.  Spontaneous pregnancy has been reported in women with 45XO karyotype.

3.  Constitutional mosaicism with 46XX is common.

4.  45XO non disjunction increases with maternal age.

5.  Constitutional mosaicism with a component of the Y chromosome is associated with gonadoblastoma.


Question 4

In relations to polycystic ovarian syndrome  (PCOS) which of the following is untrue?


1.  Serum levels of antimullerian hormone are elevated.

2.  Numbers of oocytes present in the ovaries are similar to normal women.

3.  Parents of women with PCOS are at increased risk of cardiac disease and cerebrovascular disease.

4.  Women with PCOS are at increased risk of cardiac disease post menopausally.

5.  Hyperandrogenic women with PCOS have greater risk of cardiac disease than women with PCOS and normal androgen levels.


Question 5

Which of the following is statements about precocious puberty in girls is untrue?


1.  Precocious puberty is associated with childhood obesity.

2.  Early adrenarche may indicate increased risk of having polycystic ovarian syndrome in later life.

3.  Suppression with GnRH antagonists is helpful.

4.  Improved final adult height is achieved with treatment.

5.  Craniopharyngioma is an uncommon cause.


Question 6

Which one of the following is not a proven cause of premature ovarian failure.


1.  Galactosemia

2.  Endocrine disruptors such as BPA (bisphenol-A)

3.  Fragile X mutation

4.  Deletions of the short arm of the X chromosome

5.  None of the above


Question 7

In relation to the diagnosis of pregnancy which of the following statements is true.


1.  Beta hCG is detectable in maternal serum at 10 days after ovulation.

2.  A gestational sac is visible in the uterus two weeks after ovulation.

3.  hCG is detectable in maternal urine two weeks after ovulation.

4.  The blastocyst implants at three days after ovulation and fetal hCG is detectable by polymerase chain reaction at this time.

5.  The level of hCG does not correlate with ultrasound findings.


Question 8

Endocrine disruptors


1.  Are an established cause of human disease.

2.  Are ubiquitous in the environment.

3.  Can cause transgenerational epigenetic disease.

4.  1 and 2 are true

5.  1, 2 and 3 are true.


Question 9

In relation to the progesterone receptor which of the following statements is untrue?


1.  Nuclear progesterone receptor knockout male mice are infertile.

2.  Two isoforms for nuclear progesterone receptors exist in humans.

3.  Cytoplasmic receptor ligand complexes induce measurable change in cell function.

4.  Expression of nuclear progesterone receptors is increased by oestrogen.

5.  Mutations in cell membrane progesterone receptors have been linked to human disease.


Question 10

Endogenous progesterone:

1.  Has weak mineralocorticoid effect

2.  Is produced by the adrenal gland during the follicular phase of the menstrual cycle

3.  Falls as pregnancy is established.

4.  Is insignificantly bound to albumin and sex hormone binding globulin

5.  Has 17 carbon atoms like the gonanes such as norgestimate and desogestrel

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